Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling

Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling

Gonadotropin-releasing hormone (GnRH) acts via G-protein-coupled receptors on gonadotrophs to stimulate synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. It is secreted in pulses, and its effects depend on pulse frequency, but decoding mechanisms are unknown. Here we have used an extracellular signal regulated kinase-green fluorescent protein (ERK2-GFP) reporter t...

Editorial: Gonadotropin-Releasing Hormone Receptor Signaling and Functions

(AT2) receptor: an enigmatic seven transmembrane receptor

1. Abstract 2. Introduction 3. AT2 receptor physiology: what does the AT2 receptor do? 3.1. AT2 receptor expression and tissue distribution 3.2. Developmental regulation: AT2 involvement in differentiation and apoptosis 3.3. Vascular responsiveness: AT2 dilator and constrictor actions 3.4. Cardiac fibrosis: AT2 proliferative and anti-proliferative actions 3.5. Myocardial hypertrophy: AT2 pro-gr...

Gonadotropin-releasing hormone agonist-induced pituitary apoplexy

UNLABELLED Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences. Drug-induced pituitary apoplexy is a rare but important consideration when evaluating patients with this presentation. We describe an unusual case of a patient with a known pituitary macroadenoma presenting with acute-onset third nerve palsy and headache secondary to tumour e...

Adipokinetic hormone signaling through the gonadotropin-releasing hormone receptor modulates egg-laying in Caenorhabditis elegans.

In mammals, hypothalamic gonadotropin-releasing hormone (GnRH) is a neuropeptide that stimulates the release of gonadotropins from the anterior pituitary. The existence of a putative functional equivalent of this reproduction axis in protostomian invertebrates has been a matter of debate. In this study, the ligand for the GnRH receptor in the nematode Caenorhabditis elegans (Ce-GnRHR) was found...